The integration of academic nurses in psychiatry has been described only marginally in the literature so far. For this reason, a framework model of nursing expertise in the psychiatric care context should be developed. For this, a synthesis of existing models and concepts was carried out. This synthesis led to the development of a heuristic framework model of nursing expertise in the psychiatric care context, which mainly describes the integration of different roles of academically trained nurses into practice. The framework model can be regarded as a discussion basis for the establishment of a skill and grade mix in psychiatric care practice.