The adherence of antiretroviral therapy (ART) has an important role during the treatment of persons infected with HIV. The supervision and counseling of the adherence has been taken more and more by nursing staff. In this article we present a systematic review of randomized controlled trials (RCTs), which aim is to investigate nursing interventions to effectively increase the adherence of HIV infected persons concerning ingestion of ART. The statistically significant results of 7 RCTs prove the effectiveness of behavior-orientated counseling and guidance by weekly telephone-calls. Additionally, they demonstrate that these interventions can be executed by nurses.