The recruitment of study participants and the conduct of a study are subject to various challenges. In addition to good preparation, it also requires operational and strategic action. A good starting position and a sufficiently large sample are just as important as the recognition of factors that influence the study and its course. Especially with longitudinal studies, the response rate has to be monitored and evaluated. Using the example of the ZULIDAD study (Zurich Life and Death with Advanced Dementia), which examines the end of life of people suffering from dementia, this article will cover the experiences and strategies we have made during the three-year period.